Editor

Pepsin is a powerful protein-digesting enzyme. Why does not it digest the stomach walls, which are mostly proteins? 

Difficulty: Medium

We saw that pepsin is not released in its active form. Rather it is secreted as inactive pepsinogen, which requires HCI for activation. The mucous of gastric juice form a thick coating over the inner walls of the stomach and neutralizes the HCI there. It makes pepsinogen difficult to be activated and to attack stomach walls.

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