Mosasaurs' likely body temperatures are easier to determine from tooth enamel oxygen-18 isotope data than the body temperatures of nonendothermic Late Cretaceous marine reptiles are.

Fossils of both mosaurs and nonendothermic marine reptiles have been found in roughly equal numbers in regions known to be near the poles during the Late Cretaceous, though in lower concentrations than elsewhere.

Several mosaaur fossils have been found in regions known to be near the poles during the Late Cretaceous, while relatively few fossils of nonendothermic marine reptiles have been found in those locations.

During the Late Cretaceous, seawater temperatures were likely higher throughout mosaurs' range, including near the poles, than seawater temperatures at those same latitudes are today.